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2016 Elsevier Luncheon for Medical Librarians

Apr 15, 2016

Concurrent with the 2016 Medical Library Association Conference in Toronto, Canada

 

Presentation

Life in the Fast Lane: The journey from ​squid axons to Alzheimer’s brains

 

When: Tuesday, May 17, 2016 12:00PM - 2:30PM (Toronto Time)
 

Location: Metro Toronto Convention Centre | Room 104C | 222 Bremner Blvd | Toronto (Lunch is provided at no charge to attendees)

 

 

SPACE IS LIMITED and early registration is suggested.

Register by May 6, 2016

 


 

Speaker:

Dr. Scott Brady

Professor and Head of Anatomy and Cell Biology

College of Medicine

University of Illinois at Chicago

 

 

 

About Dr. Scott Brady:

Scott Brady was born in San Antonio, TX and attended the Massachusetts Institute of Technology as an undergraduate, earning bachelor’s degrees in both Physics and Biology.  He received his PhD in 1978 from the University of Southern California in Cell and Molecular Biology for work on the role of the cytoskeleton in axonal transport. From there, he joined the laboratory of Raymond Lasek at Case Western Reserve University in Cleveland, OH as a postdoctoral fellow, continuing to study both fast and slow axonal transport.

 

In 1985, he became an assistant professor at the University of Texas Southwestern Medical Center in Dallas, TX. He remained in Dallas until 2002, when he became Professor and Head of Anatomy and Cell Biology in the College of Medicine at the University of Illinois at Chicago. Since 1985, he has also been a summer investigator conducting research at the Marine Biological Laboratory in Woods Hole, MA.  His first exposure to the MBL came as a senior research associate in 1981, when Dr. Lasek introduced him to the squid giant axon and isolated axoplasm. In the mid-1980’s, he worked with Drs. Lasek and Robert D. Allen to develop the isolated axoplasm preparation for study of fast axonal transport. This work led to his discovery in 1985 of a new family of molecular motors that were found to mediate anterograde fast axonal transport. These proteins, the kinesins, have continued to be a central component of his research in the Cell and Molecular Biology of the Neuron to the present day. His research on molecular motors was cited by Nature Cell Biology in 2009 as leading to numbers 13, 15 and 24 of 25 Milestones in Modern Cell Biology. 

 

Dr. Brady has continued his work on the molecular mechanisms of axonal transport, developing a strong interest in how it is regulated. These studies have led to the demonstration that axonal transport plays a critical role in the pathogenesis of Alzheimer’s, Parkinson’s, and Huntington’s disease as well as Amyotrophic Lateral Sclerosis. He has also studied other aspects of the cellular and molecular biology of the axon, including specializations of the axonal cytoskeleton, myelin-axon interactions and the effects of chronic stress on neuronal function as part of an overall interest in how a neuron is built and maintained for decades. He has publish more than 100 primary research papers along with more than 60 book chapters, commentaries and invited reviews. 

 

Basic Neurochemistry textbook coverDr. Brady is a fellow of the American Association for the Advancement of Science, member of various editorial boards and Editor-in-Chief of the 8th and upcoming 9th editions of the textbook Basic Neurochemistry: Principles of Cellular, Molecular, and Medical Neurobiology published by Elsevier.

 


 

Education

Massachusetts Institute of Technology, Cambridge, MA

ScB

06/1973

Physics

Massachusetts Institute of Technology, Cambridge, MA

ScB

06/1973

Biology

University of Southern California, Los Angeles, CA

PhD

08/1978

Cell and Molecular Biology

 

Positions and Employment

1982 - 1985

Senior Research Associate, Case Western Reserve University School of Medicine, Dept of Geneics and Anatomy, Cleveland, OH

1985 -

Principal Investigator, Marine Biological Laboratory, Woo, MA

1985 - 2002

Assistant/Associate Professor, Dept. of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX

2002 - 2015

Head of the Department of Anatomy, Univ of Illinois at Chicago College of Medicine, Chicago, IL

2002 -

Professor, Dept of Anatomy, Univ of Illinois at Chicago College of Medicine, Chicago, IL

 

Recent Publications of Note:

N. M. Kanaan, G. A. Morfini, N. E. Lapointe, G. F. Pigino, K. R. Patterson, Y. Song, A. Andreadis, Y. Fu, S. T. Brady and L. I. Binder (2011). Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases. The Journal of Neuroscience 31, 9858-9868 

 

Y. Chu, G. A. Morfini, L. B. Langhamer, Y. He, S. T. Brady and J. H. Kordower (2012). Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 135, 2058-73

 

Y. Song, L. L. Kirkpatrick, A. B. Schilling, D. L. Helseth, N. Chabot, J. W. Keillor, G. V. W. Johnson and S. T. Brady (2013). Transglutaminase and Polyamination of Tubulin: Posttranslational Modification for Stabilizing Axonal Microtubules. Neuron 78, 108-123.

 

Y. Song, M. Nagy, W. Ni, N. K. Tyagi, W. A. Fenton, F. Lopez-Giraldez, J. D. Overton, A. L. Horwich and S. T. Brady (2013). Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. Proc Natl Acad Sci USA 110, 5428-33.

 

Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, et al. Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase. PLoS One. 2013;8(6):e65235. doi: 10.1371/journal.pone.0065235. PubMed PMID: 23776455; PubMed Central PMCID: PMC3680447.

 


SPACE IS LIMITED and early registration is suggested.

Register by May 6, 2016

 

 

 

 

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